Boosters are best for collection building, limited play, and the fun of opening packs
By combining multiple Runes of Might, Runes of Speed, and Runes of Sustenance onto the same creature, you're going to draw a ton of cards (hopefully more free runes) and swing in for lethal

Awaken the Erstwhile Balancing Act Chandra Ablaze Creeping Dread Cunning Lethemancer Dark Deal Delirium Skeins Dragon Mage Earsplitting Rats Enemy of Enlightenment Fanatic of the Harrowing Flux Gutmorn, Pactbound Servant Ill-Gotten Gains Incendiary Command Jace's Archivist Kardur's Vicious Return Kefka, Court Mage Largepox (playtest) Liliana of the Veil Liliana, Defiant Necromancer Liliana, Waker of the Dead Magus of the Jar Magus of the Wheel Marsh Crocodile Memory Jar Miasmic Mummy Mindlash Sliver Mindslicer Naktamun Lorespinner Neheb, the Worthy Rankle's Prank Rankle, Master of Pranks Reforge the Soul Rix Maadi, Dungeon Palace Rotting Rats Runehorn Hellkite Seek Bolas's Counsel (playtest) Sensation Gorger Serum Raker Sibsig Icebreakers Sire of Insanity Strategy, Schmategy Strongarm Tactics Stronghold Rats Wheel of Fate Wheel of Fortune Whispering Madness Windfall

The textured foil version of Mana Drain from the Breaking News element of the set means that it going to be extra rare, so the odds of opening this variant will be incredibly low