Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP mal-hexanoyl Product Name DOTA-tris(t-Bu)ester-C3-alcohol Synonyms CAS

Product Name DOTA-tris(t-Bu)ester-C3-alcohol Synonyms CAS Number n/a Related CAS Molecular Formula C31H59N5O8 Molecular Weight 629

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation

Product Name Thalidomide-O-acetamido-C3-azide Synonyms Thalidomide-4'-O-acetamido-C3-azide CAS Number n/a Related CAS Molecular Formula C18H18N6O6 Molecular Weight 414

Nature 2020

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG8)-PNP mal-hexanoyl Product Name DOTA-tris(t-Bu)ester-C3-alcohol Synonyms CASSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating