Pay in 4 interest-free payments of $123.75 Learn more
Ships within 48 hours · Estimated delivery Aug 30 - Sep 4
NRX-252114 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome
216 Purity (HPLC) >= 95% Solubility DMSO
364 SMILES OCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
486 SMILES: NCCCCCNC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only
DBCO-Lys(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE deuterium-labeled-amine NRX-252114 acts as molecular glueSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
