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CP-CPY pab-mpeg which recruit the VHL or

SKU: 36106537332

4.0
USD195.00 USD225.00

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Description

which recruit the VHL or CRBN-ubiquitin E3 ligases to induce the degradation of SNAP-fusion proteins

Product Name Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8) Synonyms CAS Number Related CAS Molecular Formula C51H87N7O19 Molecular Weight 1102

Product Name DOTA-tris(t-Bu)ester-C6-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C41H71N7O10 Molecular Weight 822

a Azide-Dap(m-PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility

CP-CPY pab-mpeg which recruit the VHL orSNAP tag is a self labeling protein derived from human O6 alkylguanine DNA alkyltransferase. At 20 kDa, SNAP tag is smaller than HaloTag (33 kDa), potentially reducing interference with the tagged proteins function. SNAP tag reacts with covalently with benzylguanine (BG)or chloropyrimidine (CP) derivatives, forming a stable thioether bonds that ensures durability for long term experiments or harsh conditions. SNAP tag can be used alongside other tags

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